Dec 21, 2022

Public workspaceTissue perfusion parameter-guided initial resuscitation in adult patients with sepsis or septic shock: A systematic review and network meta-analysis

DOI
dx.doi.org/10.17504/protocols.io.14egn29oyg5d/v1
  • 1School of Nursing, Sapporo City University, Kita 11 Nishi 13, Chuo-ku, Sapporo, Hokkaido 060-0011, Japan;
  • 2Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan;
  • 3Departmennt of Traumatology and Critical Care Medicine, National Defense Medical College Hospital, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan;
  • 4Department of Anesthesiology, Nagoya University Hospital, 6 5 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan;
  • 5Department of Critical Care Medicine, Nerima Hikarigaoka Hospital, 2-5-1, Hikarigaoka, Nerima-ku, Tokyo, 179-0072, Japan;
  • 6Department of Critical Care Medicine, Fukuoka Children’s Hospital, 5-1-1 Kashii-Teriha, Higashi-ku, Fukuoka, 813-0017, Japan;
  • 7Department of Emergency and Critical Care Medicine, Saitama Medical Center, Jichi medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan;
  • 8Department of Emergency and Intensive Care Medicine, JA Hiroshima General Hospital, 1-3-3 Jigozen, Hatsukaichi-City, Hiroshima, 738-8503, Japan
Tomoki Kuribara
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DOI: dx.doi.org/10.17504/protocols.io.14egn29oyg5d/v1
Protocol Citation: Tomoki Kuribara, Tetsuya Yumoto, Kohei Yamada, Takehito Sato, Shigeru Koba, Kenichi Tetsuhara, Masahiro Kashiura, Masaaki Sakuraya,MD, MPH 2022. Tissue perfusion parameter-guided initial resuscitation in adult patients with sepsis or septic shock: A systematic review and network meta-analysis. protocols.io https://dx.doi.org/10.17504/protocols.io.14egn29oyg5d/v1
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License,  which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it's working
Created: December 18, 2022
Last Modified: December 21, 2022
Protocol Integer ID: 74175
Abstract
Background: Hemodynamic management is crucial in treating patients with sepsis or septic shock. To date, several tissue perfusion parameters have been suggested, however; the optimal parameter is not well defined.

Objective: This study aims to examine whether and which tissue perfusion parameter-guided therapy during initial resuscitation in adult patients with sepsis or septic shock improved patients’ outcomes.

Design: Systematic review and network meta-analysis.

Data sources: We will search the following electronic bibliographic databases: Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE via PubMed, Web of Science, and Igaku-Chuo-Zasshi. We will also search the World Health Organization International Clinical Trials platforms Search Portal (ICTRP) and ClinicalTrials.gov. for ongoing trials. There will be no language restriction.

Analysis: We will have two types of meta-analysis planned. First, direct pairwise meta-analysis will be conducted using random effect models. Second, network comparison meta-analysis will be conducted using a frequentist approach with multivariate random effect meta-analysis.
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