Sep 23, 2024
Study of prescription-indication of antivirals for herpesviruses in a Colombian population. A cross-sectional study
- 1Universidad Tecnologica de Pereira - Audifarma SA
- UTP-Audifarma
Protocol Citation: Jorge Machado Alba 2024. Study of prescription-indication of antivirals for herpesviruses in a Colombian population. A cross-sectional study. protocols.io https://dx.doi.org/10.17504/protocols.io.dm6gpzkk1lzp/v1
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it's working
Created: September 23, 2024
Last Modified: September 23, 2024
Protocol Integer ID: 108185
Keywords: Antiviral Agents; Acyclovir; Drug prescriptions; Inappropriate Prescribing; Colombia; Pharmacoepidemiology.
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Abstract
Introduction:
Herpesviruses are among the most common pathogens worldwide.
Objective: To
determine the prescription patterns and indications for the use of antivirals
for herpesviruses in a group of patients from Colombia.
Methods: This was a
cross-sectional study on the use of antivirals for treating outpatients with
herpesviruses between November 2023 and January 2024 in a Colombian population
database. The approved and unapproved indications were determined according to
the records of the Food and Drug Administration (FDA) and the National
Institute of Food and Drug Surveillance (INVIMA) of Colombia. Descriptive
analysis was carried out.
Results: In total, 17,275
patients were identified, with an average age of 47.5 ± 21.2 years, and 59.1%
were women. The most frequently prescribed antiviral was acyclovir, and the
most frequently used antiviral agent was herpes zoster (47.6%). In total, 9.8%
of the prescriptions were used for unapproved indications, with vaginitis/vulvitis/vulvovaginitis
(3.2%) standing out. In total, 55.2% were treated only with oral dosage forms,
24.6% with oral and topical dosage forms, and 20.2% with only topical dosage
forms. The concomitant prescription of systemic (17.0%) and topical (8.5%)
antimicrobial agents was common.
Conclusions:
Acyclovir was the most commonly prescribed antiviral for the management of herpes
zoster. Adherence to clinical practice guidelines was not adequate in some
cases, indicating unapproved uses and uses in entities where efficacy is very
doubtful or limited, especially with topical pharmaceutical forms. The
concomitant prescription of other antimicrobials was common.
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