The estimation of vitamin D levels revealed that individuals in caries free group(N=138) showed significantly higher vitamin d levels in comparison to caries active group (p=0.000, student ‘t’ test) with a mean value of 29.44 ng/ µl in caries free and 20.02 ng/ µl in caries active group. The assay showed no significant variation in salivary cathelicidins (LL-37) levels in both the groups even the mean value in caries free is higher i.e., 7.07 ng/ µl. There is a significant association between dental caries and VDR Taq1 polymorphism(p=0.000) and VDR Apa1 polymorphism (p=0.000), there is no significant association between VDR Bsm1 polymorphism and dental caries(p=0.973). In VDR gene SNP’s Taq1 , CC is the protective factor, and allele ‘C’ is associated with control and allele ‘T’ is associated with cases. In SNP Apa1 , Allele ‘A’ is associated with controls and therefore is the protective factor and allele ‘C’ is associated with cases. The multiple comparisons show a significant association between VDR Taq1 polymorphism and salivary vitamin d levels in caries active group (p=0.05), there was no significant association between salivary vitamin D and VDR Apa1, Bsm1 polymorphisms.