((randomized*:ti,ab,kw OR randomly:ti,ab,kw OR randomised:ti,ab,kw OR randomization:ti,ab,kw OR randomisation:ti,ab,kw OR placebo*:ti,ab,kw OR blind*:ti,ab,kw OR pragmatic:ti,ab,kw OR 'randomized controlled trial'/exp OR 'adaptive clinical trial'/exp OR 'controlled clinical trial'/exp) AND ('coronavirus disease 2019'/exp OR 'SARS-Cov-2 variant 501Y.V1'/exp OR 'coronavirus spike glycoprotein'/exp OR 'novel coronavirus':ti,kw,ab OR 'ncov 2019':ti,kw,ab OR 2019nCoV:ti,kw,ab OR 'corono virus':ti,ab,kw OR 'corona virus disease 19':ti,ab,kw OR 'coronavirus 2':ti,ab,kw OR 'covid 19':ti,kw,ab OR 'COVID-19 testing'/exp OR 'SARS-CoV-2 vaccine'/exp OR 'coronavirus receptor'/exp OR ((covid NEAR/2 19):ti,kw,ab) OR ((sars NEAR/2 'cov 2'):ti,kw,ab) OR '2019 ncov':ti,kw,ab OR ((wuhan:ti,kw,ab OR hubei:ti,kw,ab) AND coronavirus*:ti,kw,ab) OR ([2019-2020]/py AND (new:ti,kw,ab OR novel:ti,kw,ab OR pandemic:ti,kw,ab OR epidemic:ti,kw,ab) AND ('coronavirus infection'/exp OR coronavirus*:ti,kw,ab OR coronavirinae/de OR 'corona virus*':ti,kw,ab))) AND 'human'/de AND [embase]/lim NOT ([embase]/lim AND [medline]/lim) AND [english]/lim) NOT ('mental disease'/exp OR depression:ti OR 'systematic review'/exp OR 'review'/exp OR 'editorial'/exp OR 'meta analysis'/exp OR 'case report'/exp OR 'letter'/exp)