From the perspective of the documentation of plant biological diversity, herbaria are the repository of intraspecific and interspecific variability. The rich assortments contained in these collections essay the diversity over time and space, in addition to fulfilling a referential function, keeping material testimonies of works in different areas of knowledge. This project aims to establish an integrated platform for the development of the application of chemotaxonomy as a classificatory parameter using samples from botanical collections. For this, this project proposes the investigation and application of quality control samples and analysis using a validated method following an analytical rigor that allows data obtained from different batches to be evaluated altogether. With the optimization and validation of the method, it is expected to establish a unique procedure, which can be adopted by other research groups that are interested in contributing to a progressive growth of analytical data from samples collected in herbaria in Brazil and in the World; this includes the logistics for disseminating the quality control samples for batch corrections. Initially, Solanaceae species will be used as proof of concept. Thus, it is hoped that it will be possible to point out the metabolic distinction in the form of biomarkers resulting from multivariate analyzes that are characteristic of genera and species within the Solanaceae family. This project will also allow the mass cataloging of NP of the analyzed samples; all identified compounds will have their spectral data submitted to open databases/repositories. Still, it will be possible to integrate efforts in the search for organisms and compounds of high value from different natural sources or inspired by them, applying chromatographic, MS and NMR techniques, in combination with the methodologies of dereplication and chemometric analysis and with the aid of studies using in silico molecular modeling.