Jun 06, 2024
Version 1
NIBS using tDCS to mitigate aggression V.1
- 1ISTCS.org
Protocol Citation: Paola Di Maio 2024. NIBS using tDCS to mitigate aggression . protocols.io https://dx.doi.org/10.17504/protocols.io.261ge5597g47/v1Version created by Paola Di Maio
Manuscript citation:
Source of the protocol: JNeuro
https://www.jneurosci.org/content/jneuro/38/29/6505.full.pdf
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it's working
Created: June 03, 2024
Last Modified: June 08, 2024
Protocol Integer ID: 101134
Keywords: neuromodulation, brain stimulation
Disclaimer
The protocol is published to facilitate sharing and reuse of non invasive neuromodulation research outcomes. The protocol describes a procedure which has been tested, peer reviewed and published by reputable sources with supporting data.
The source of the protocol together with critical information about its safe application are provided without warranties.
The author is not responsible for unexpected, undesired or adverse outcomes of the application of the protocol.
Readers, researchers, clinicians and healthpractictioners accessing this material are responsible for verifying the content and relevance of the protocol and its application, and use it at their own discretion, taking into account the the safety warnings.
Abstract
Protocol Description: Non Invasive Neuromodulation procedure using tDCS (transcranial direct current stimulation) to mitigate aggressive behavior in healthy adults
Condition: tendency to exhibit overly aggressive behavior
Safety: The procedure must be administered by trained personnel, and the subject must obtained medical clearance
Contraindications: Do not administer this procedure if the subject has metallic implants near the
electrode sites; is epileptic; has unstable medical conditions; neurological, cardiovascu-
lar, or psychiatric illness; participates in another noninvasive brain
stimulation study on the same day; has history of adverse reactions to tDCS;
Do not apply electrodes to skin with lesions
tDCS intervention. using a battery-driven, constant-current stimulator .
DLPFC pre frontal cortex
Tdcs transcranial direct current stimulation
Guidelines
Safety Warning: The procedure Must be administered by trained personnel ; the subject must obtain medical clearance
Materials
tDCS administered by trained personnel using a battery-driven, constant-current stimulator (adherent to international standards) plus Two anodal electrodes
A constant currentof 2 mA (1 mA to each DLPFC site) applied for 20 min through
saline-soaked sponge electrodes (5 5 cm).
A single extracephalic cathodal electrode (5 7 cm) ia placed at the posterior base of the neck
to minimize unintentional effects of inhibitory stimulation on brain
activity.
Safety warnings
Do not administer this procedure if the subject has metallic implants near the
electrode sites; is epileptic; has other unstable medical conditions; neurological, cardiovascu-
lar, or psychiatric illness; participates in another noninvasive brain
stimulation study on the same day; has history of adverse reactions to tDCS;
Do not apply the electrode on skin with lesions
Ethics statement
Subject must be informed about the protocol followed in procedure before it starts, its safety warnings, the expected duration and has given explicit consent.
The procedure has been developed and tested in research laboratory on 81 subjects, pre trial, (see Source)
tDCS is associated with minimal side effects. No major adverse events were reported over the duration of the study
Before start
Two hours before or after main meals
wearing no metal objects
comfortable clothing
sitting in semi reclined position
Protocol Description
Protocol Description
Two anodal electrodes are placed over the DLPFC bilaterally (F3 and F4) according to the International 10 –20 EEG system.
A constant current of 2 mA (1 mA to each DLPFC site) is applied for 20 min through saline-soaked sponge electrodes (5 5 cm).
A single extracephalic cathodal electrode (5 7 cm) is placed at the posterior base of the neck to minimize unintentional effects of inhibitory stimulation on brain Activity.
Following standard tDCS protocol, stimulation commences after 30 s ramp-up period. The current is ramped down over the last 2 s.
Check the subject throughout the procedure and discontinue if the subject shows discomfort
Safety Warnings
Safety Warnings
Use tDCS equipment and accessories compliant with international standards, by trained personnel
In pre clinical studies, the procedure can mitigate Aggressive behaviour
Protocol references
Akman D, Normandeau A, Sellin T, Wolfgang M (1968) Towards the mea-
surement of criminality in Canada: a replication study. Acta Crimino-
logica 1:135–260. CrossRef
Alegria AA, Radua J, Rubia K (2016) Meta-analysis of fMRI studies of dis-
ruptive behavior disorders. Am J Psychiat 173:1119 –1130. CrossRef
Medline
American Psychiatric Association (2013) Diagnostic and statistical manual of
mental disorders (5th ed.). Washington, DC: American Psychiatric
Association.
Anderson SW, Bechara A, Damasio H, Tranel D, Damasio AR (1999) Im-
pairment of social and moral behavior related to early damage in human
prefrontal cortex. Nat Neurosci 2:1032–1037. CrossRef Medline
Armstrong TA, Boutwell BB (2012) Low resting heart rate and rational
choice: integrating biological correlates of crime in criminological theo-
ries. J Crim Jus 40:31–39. CrossRef
Beauchaine TP, Neuhaus E, Brenner SL, Gatzke-Kopp L (2008) Ten good
reasons to consider biological processes in prevention and intervention
research. Dev Psychopathol 20:745–774. Medline
Brunoni AR, Nitsche MA, Bolognini N, Bikson M, Wagner T, Merabet L,
Edwards DJ, Valero-Cabre A, Rotenberg A, Pascual-Leone A, Ferrucci R,
Priori A, Boggio PS, Fregni F (2012) Clinical research with transcranial
direct current stimulation (tDCS): challenges and future directions. Brain
Stimul 5:175–195. CrossRef Medline
Butchart A, Phinney A, Check P, Villaveces A (2004) Preventing violence: a
guide to implementing recommendations of the World Report on Vio-
lence and Health. Geneva, Switzerland: Department of Injuries and Vio-
lence Prevention, World Health Organization.
Chen CY, Raine A, Chou KH, Chen IY, Hung D, Lin CP (2016) Abnormal
white matter integrity in rapists as indicated by diffusion tensor imaging.
BMC Neurosci 17:45. CrossRef Medline
Committee for Proprietary Medicinal Products (CPMP) (2004) Committee for
Proprietary Medicinal Products (CPMP): points to consider on adjustment for
baseline covariates. Statistics in medicine 23:701–709. CrossRef Medline
Cui J, Tkachenko O, Gogel H, Kipman M, Preer LA, Weber M, Divatia SC, Demers
LA, Olson EA, Buchholz JL, Bark JS, Rosso IM, Rauch SL, Killgore WD (2015)
Microstructure of frontoparietal connections predicts individual resistance to
sleep deprivation. Neuroimage 106:123–133. CrossRef Medline
Dalwani M, Sakai JT, Mikulich-Gilbertson SK, Tanabe J, Raymond K, Mc-
Williams SK, Thompson LL, Banich MT, Crowley TJ (2011) Reduced
cortical gray matter volume in male adolescents with substance and con-
duct problems. Drug Alcohol Depend 118:295–305. CrossRef Medline
Damasio AR (2000) A neural basis for sociopathy. Arch Gen Psychiatry 57:
128 –129. CrossRef
Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR (1994) The
return of Phineas Gage: clues about the brain from the skull of a famous
patient. Science 264:1102–1105. CrossRef Medline
Dambacher F, Schuhmann T, Lobbestael J, Arntz A, Brugman S, Sack AT
(2015a) No effects of bilateral tDCS over inferior frontal gyrus on response
inhibition and aggression. PloS One 10:e0132170. CrossRef Medline
Dambacher F, Schuhmann T, Lobbestael J, Arntz A, Brugman S, Sack AT
(2015b) Reducing proactive aggression through non-invasive brain
stimulation. Soc Cogn Affect Neurosci 10:1303–1309. CrossRef Medline
Dewall CN, Finkel EJ, Lambert NM, Slotter EB, Bodenhausen GV, Pond RS Jr