16h before stereotactic surgeries, load Alzet‱ Mini-Osmotic Pumps (model 2004) with 1.47μg/uL of FMF-04-159-2 (R&D Systems 7158, Minneapolis, MN, USA in vehicle solution containing 8% DMSO (Fisher Scientific, BP231, Hampton, NH, USA), 2% Tween 80 (Fisher Scientific, BP338-500) and 90% ddH2O). These pumps administer the solution at 0.35mg/kg/day.