Nov 20, 2021
Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
- Jorge Enrique Machado-Alba1,
- Luis Fernando Valladales Restrepo1,
- Manuel E Machado Duque1,
- Andres Gaviria Mendoza1
- 1Universidad Tecnológica de Pereira
External link: https://doi.org/10.1371/journal.pone.0260169
Protocol Citation: Jorge Enrique Machado-Alba, Luis Fernando Valladales Restrepo, Manuel E Machado Duque, Andres Gaviria Mendoza 2021. Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. protocols.io https://dx.doi.org/10.17504/protocols.io.bud5ns86
Manuscript citation:
Machado-Alba JE, Valladales-Restrepo LF, Machado-Duque ME, Gaviria-Mendoza A, Sánchez-Ramírez N, Usma-Valencia AF, Rodríguez-Martínez E, Rengifo-Franco E, Forero-Supelano VH, Gómez-Ramirez DM, Sabogal-Ortiz A (2021) Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia. PLoS ONE 16(11): e0260169. doi: 10.1371/journal.pone.0260169
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
Created: April 21, 2021
Last Modified: November 20, 2021
Protocol Integer ID: 49309
Abstract
Introduction:Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality.
Objective: To identify the factors associated with admission to intensive care units (ICUs) and mortality in patients with COVID-19 from 4 clinics in Colombia.
Methods: This was a follow-up study of a cohort of patients diagnosed with COVID-19 between March and August 2020. Sociodemographic, clinical (Charlson comorbidity index and NEWS 2 score) and pharmacological variables were identified. Multivariate analyses were performed to identify variables associated with the risk of admission to the ICU and death (p<0.05).
Results: A total of 780 patients were analyzed, with a median age of 57.0 years; 61.2% were male. On admission, 54.9% were classified as severely ill, 65.3% were diagnosed with acute respiratory distress syndrome, 32.4% were admitted to the ICU, and 26.0% died. The factors associated with a greater likelihood of ICU admission were severe pneumonia (OR: 9.86; 95%CI:5.99-16.23), each 1-point increase in the NEWS 2 score (OR:1.09; 95%CI:1.002-1.19), history of ischemic heart disease (OR:3.24; 95%CI:1.16-9.00), and chronic obstructive pulmonary disease (OR:2.07; 95%CI:1.09-3.90).The risk of dying increased in those older than 65 years (OR:3.08; 95%CI:1.66-5.71), in patients with acute renal failure (OR:6.96; 95%CI:4.41-11.78), admitted to the ICU (OR:6.31; 95%CI:3.63-10.95), and for each 1-point increase in the Charlson comorbidity index (OR:1.16; 95%CI:1.002-1.35).
Conclusions:Factors related to increasing the probability of requiring ICU care or dying in patients with COVID-19 were identified, facilitating the development of anticipatory intervention measures that favor comprehensive care and improve patient prognosis.
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