Mar 28, 2023
Efeito do uso de antidepressivos na redução de escores de depressão em mulheres com câncer de mama em tratamento com quimioterápicos antineoplásicos: Revisão Sistemática e metanálise
- 1UNESC
Protocol Citation: brunosilva 2023. Efeito do uso de antidepressivos na redução de escores de depressão em mulheres com câncer de mama em tratamento com quimioterápicos antineoplásicos: Revisão Sistemática e metanálise. protocols.io https://dx.doi.org/10.17504/protocols.io.6qpvr4y6ogmk/v1
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Other
Protocol for starting a Systematic review
Created: March 17, 2023
Last Modified: March 28, 2023
Protocol Integer ID: 79010
Abstract
PRotocol for a sytematic review
Title
Title
Effect of the use of antidepressants on the reduction of depression scores in women with breast cancer undergoing treatment with antineoplastic chemotherapy: Systematic Review and meta-analysis
Original title
Original title
Efeito do uso de antidepressivos na redução de escores de depressão em mulheres com câncer de mama em tratamento com quimioterápicos antineoplásicos: Revisão Sistemática e metanálise
Start date
Start date
08/01/2
Anticipated completion date
Anticipated completion date
10/15/23
Stage of review at time of this submission.
Stage of review at time of this submission.
Preliminary searches:
Started: No
Completed: No
Piloting of the study process:
Started: No
Completed: No
Formal screening of search results against eligibility criteria:
Started: No
Completed: No
Data extraction:
Started: No
Completed: No
Risk of bias (quality) assessment:
Started: No
Completed: No
Data analysis:
Started: No
Completed: No
Named contact
Named contact
Bruno Spalenza da Silva
Named contact email
Named contact email
brunosilva821@hotmail.com
Named contact phone number
Named contact phone number
55 27 999395729
Organisational affiliation of the review
Organisational affiliation of the review
Centro Universitario do Espirito Santo (UNESC)
Organisation web address
Organisation web address
https://www.unesc.br
Review team members and their organisational affiliations
Review team members and their organisational affiliations
Mrs Bruno Spalenza da Silva. Centro Universitario do Espirito Santo (UNESC).
Mrs Kaique Avancini Soerio. Centro Universitario do Espirito Santo (UNESC).
Miss Mirele Morais Mayrink. Centro Universitario do Espirito Santo (UNESC).
Miss Paloma de Araujo Figueira. Centro Universitario do Espirito Santo (UNESC).
Funding sources/sponsors
Funding sources/sponsors
Centro Universitario do Espirito Santo (Scientific initiation scholarship).
Conflicts of interest
Conflicts of interest
None.
Collaborators
Collaborators
None.
Review question
Review question
Are antidepressants effective for depressive symptoms caused by treatment with antineoplastic chemotherapy?
Searches
Searches
PubMED, CENTRAL, Embase and CINAHL databases will be used to search for articles. All terms related to depression, antidepressants, randomized clinical trials and breast cancer will be used in the search.
Condition or domain being studied
Condition or domain being studied
According to Inca (National Cancer Institute), breast cancer is a disease caused by the uncontrolled proliferation of abnormal breast cells, which form a tumor capable of invading and multiplying in other organs. This type of cancer is the most recurrent malignant disease among the female population. Among women with breast cancer, about 40% have a depressive condition and about 10 to 25% are diagnosed with major depression (CALLARI, 2013).
Depression is a chronic psychiatric illness, marked by mood swings, such as anguish, sadness and lack of interest. Depression is the psychiatric disorder that most prevails in cancer patients, being a limiting factor in the therapeutic process of cancer, due to the difficulty of accurate diagnosis and the high hospitalization of patients, thus reducing adherence to chemotherapy treatment.
Participants/population
Participants/population
Inclusion: women with breast cancer diagnosed with depression undergoing chemotherapy treatment; Exclusion: women with breast cancer, without diagnosis of depression; children; men.
Intervention(s), exposure(s)
Intervention(s), exposure(s)
Patients with breast cancer and diagnosed with depression, who start the administration of antidepressants during the chemotherapy process with antineoplastic agents, are subject to drug reactions that can be harmful to said organisms. Considering that there are restrictions on the use of some antidepressants in line with breast cancer therapy, as they compromise the action of chemotherapy drugs, this work aims to verify the effectiveness of this joint treatment in women with such a pathology, evaluating the possible drug reactions and the its adverse effects when associated with chemotherapy.
Comparator(s)/control
Comparator(s)/control
Not applicable.
Types of study to be included
Types of study to be included
We will include all randomized clinical trials that used depression scores in the evaluation of treatment of depressive symptoms in women with breast cancer.
Context
Context
Articles/studies that discuss depression and its treatment with antidepressants, breast cancer and its psychological effects, chemotherapy and its effects. Surveys done in other countries will also be used.
Main outcome(s)
Main outcome(s)
The main objective of this research is to show the effects of antidepressants in reducing depression scores in women with breast cancer undergoing chemotherapy.
Additional outcome(s)
Additional outcome(s)
List the most effective antidepressants for these cases and discuss the effect of breast cancer and its treatment on the patients' psychology.
Data extraction (selection and coding)
Data extraction (selection and coding)
After selecting the articles, the titles and abstracts will be analyzed by 2 evaluators for selection, and in case of disagreement, a third evaluator will judge the inclusion or exclusion. After selecting the articles, the data will be manually extracted and analyzed by a meta-analysis using the Revision Manager 5.4 ® software. The heterogeneity between the results will also be evaluated, and the final result will be expressed in Confidence Intervals (CI95%) and graphically through the forest plot. The risk of bias analysis will be performed using the RoB 2.0 tool, and the writing will follow the PRISMA criteria. If possible, subgroup analyzes will be performed for each class of antidepressants.
All data from all steps will be stored.
Risk of bias (quality) assessment
Risk of bias (quality) assessment
RoB2
Strategy for data synthesis
Strategy for data synthesis
The formal method of combining individual study data including, as applicable, information about statistical models that will be fitted (e.g. risk ratios for individual studies will be combined using a random effects meta-analysis) or methods of synthesising qualitative data.
Analysis of subgroups or subsets
Analysis of subgroups or subsets
If there is a need for subgroup analysis, a meta-regression will be performed.
Type and method of review
Type and method of review
Intervention.
Language
Language
Portuguese - BR and English.
Country
Country
Brazil.
Keywords
Keywords
Antidepressant; Depression; Breast cancer; Depression scores; Chemotherapy; Medicines; Treatment; Women;
Current review status
Current review status
initial: the review is being started with a search strategy for the analysis of articles and data relevant to the construction of the work.