Nov 02, 2023
An overview of growth factors as the potential link between psoriasis and metabolic syndrome.
- Mateusz Matwiejuk1,
- Hanna Myśliwiec1,
- Adrian Chabowski2,
- Iwona Flisiak1
- 1Department of Dermatology and Venereology, Medical University of Bialystok;
- 2Department of Physiology, Medical University of Bialystok
Protocol Citation: Mateusz Matwiejuk, Hanna Myśliwiec, Adrian Chabowski, Iwona Flisiak 2023. An overview of growth factors as the potential link between psoriasis and metabolic syndrome. . protocols.io https://dx.doi.org/10.17504/protocols.io.6qpvr3rwzvmk/v1
Manuscript citation:
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
We use this protocol and it's working
Created: November 01, 2023
Last Modified: November 02, 2023
Protocol Integer ID: 90258
Abstract
Psoriasis
is a chronic, complex, immunologically mediated, systematic disease that can
not only affect the skin but also the joints, and nails. It may coexist with
various other disorders such as depression, psoriatic arthritis, cardiovascular
diseases, diabetes mellitus, and metabolic syndrome. In particular, the
potential link between psoriasis and metabolic syndrome is worthy of an
attention issue. A dysregulated level of growth factors could potentially
contribute to the disturbances of keratinocyte proliferation, inflammation, and
severity of itch. However, the
pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome,
remain incompletely elucidated. Growth factors and their abnormal metabolism may
be the potential link connecting this conditions. Overall, the objective of
this review is to analyze the role of growth factors disturbances in psoriasis
and in metabolic syndrome.
Materials
A medical literature search of PubMed (1985–present) conducted in the
spring of 2023, was performed using appropriate terms without date limitations.
The main subject of the research was to identify the role of growth factors as
a potential bridge between metabolic syndrome and psoriasis. Medical subject
headline terms included “b-FGF and skin”, “b-FGF and skin diseases”, “b-FGF and
psoriasis”, “b-FGF and metabolic syndrome”, “HGF and skin”, “HGF and skin
diseases”, “HGF and psoriasis”, “HGF and metabolic syndrome”, “NGFb and skin”,
“NGFb and skin diseases”, “NGF and psoriasis”, “NGFb and metabolic syndrome”,
“SCF and skin”, “SCF and skin diseases”, “SCF and psoriasis”, “SCF and
metabolic syndrome”, “PDGF-BB and skin”, “PDGF-BB and skin diseases”, “PDGF-BB
and psoriasis”, “PDGF-BB and metabolic syndrome”, “M-CSF and skin”, “M-CSF and
skin diseases”, “M-CSF and psoriasis”, and “M-CSF and metabolic syndrome”.
Identification of records. Databases (n = 1) Pubmed
Screening of records
Records screened (n = 1579)
Records excluded (n = 1372 )
No data available
Abstracts
Reports assesed for eligibility (n = 207 )
Reports excluded
Reason 1 (n = 38 ) Duplications
Reason 2 (n = 77 ) Out of scope
Studies included in review (n = 92 )