Mar 07, 2023
ACTION Biomarker Study
- Fiona A. Hagenbeek1,2,
- Jenny van Dongen1,2,3,
- Peter J. Roetman4,
- Erik A. Ehli5,
- Meike Bartels1,2,
- Robert R. J. M. Vermeiren4,6,
- Dorret I. Boomsma1,2,3,
- ACTION Consortium7
- 1Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands;
- 2Amsterdam Public Health Research Institute, Amsterdam, the Netherlands;
- 3Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands;
- 4LUMC-Curium, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Oegstgeest, the Netherlands;
- 5Avera Institute for Human Genetics, Sioux Falls, South Dakota, United States of America;
- 6Youz, Parnassia Psychiatric Institute, the Hague, the Netherlands;
- 7Members of the ACTION Consortium are listed in Bartels et al. (2018, https://doi.org/10.1007/s00787-018-1169-1)
Protocol Citation: Fiona A. Hagenbeek, Jenny van Dongen, Peter J. Roetman, Erik A. Ehli, Meike Bartels, Robert R. J. M. Vermeiren, Dorret I. Boomsma, ACTION Consortium 2023. ACTION Biomarker Study. protocols.io https://dx.doi.org/10.17504/protocols.io.eq2ly7qkwlx9/v1
License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Protocol status: Working
Created: March 07, 2023
Last Modified: March 07, 2023
Protocol Integer ID: 78271
Keywords: childhood aggression, childhood behavior problems, mental health, buccal cells, urine, genetics, epigenetics, DNA methylation, biomarkers, metabolomics, amines, organic acids, steroid hormones, multi-omics
Funders Acknowledgement:
European Union Seventh Framework Program (FP7/2007-2013)
Grant ID: 602768
Abstract
The goal of ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies) was to identify precursors, features, and consequences of childhood aggression using epidemiological and omics-driven studies. A considerable effort within ACTION was the collection of new omics data in children with low and high aggressive behavior. To this end, the ACTION project included large-scale collection of biological samples in children from the Netherlands Twin Register (NTR), a twin cohort from the general population, and a cohort of children referred for psychiatric treatment (LUMC-Curium). Together these cohorts comprise the ACTION Biomarker Study. This documentation describes the study design and data collection for the ACTION Biomarker Study.
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